Gram-negative bacteria are leading causes of healthcare-associated bloodstream infections,
with up to 33.9% associated mortality 30 days after an episode of Gram-negative bloodstream
infection (GNBSI) [
[1]
]. Higher mortality rates from hospital-onset GNBSIs compared with community-onset
GNBSIs have also been widely reported [
[1]
]. Antimicrobial resistance, especially amongst Gram-negative bacteria, poses a huge
global health crisis [
[2]
]. As such, the UK Government has set a target to halve the incidence of healthcare-associated
GNBSIs by 2024/2025 [
[2]
]. Identifying avoidable causes of healthcare-associated GNBSIs would inform effective
preventive strategies.To read this article in full you will need to make a payment
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References
- Thirty-day all-cause mortality following MRSA, MSSA and Gram-negative bacteraemia and C. difficile infections, 2020 to 2021.UK Health Security Agency, London2021 (Available at:)
- Annual epidemiological commentary: Gram-negative bacteraemia, MRSA bacteraemia, MSSA bacteraemia and C. difficile infections, up to and including financial year April 2020 to March 2021.Public Health England, London2021
- Rising rates of hospital-onset Klebsiella spp. and Pseudomonas aeruginosa bacteraemia in NHS acute trusts in England: a review of national surveillance data, August 2020–February 2021.J Hosp Infect. 2022; 119: 175-181
- English surveillance programme for antimicrobial utilisation and resistance (ESPAUR).UK Health Security Agency, London2021 (Available at:)
- Prevention of hospital-acquired pneumonia in non-ventilated adult patients: a narrative review.Antimicrob Resist Infect Control. 2016; 5: 43
- Prevention of VAP: endless evolving evidences – systematic literature review.Nurs Forum. 2021; 56: 905-915
- Characteristics of hospital-acquired and community-onset blood stream infections, south-East Austria.PLoS One. 2014; 9e104702
- Epidemiology and outcome of nosocomial and community-onset bloodstream infection.J Clin Microbiol. 2003; 41: 3655-3660
Article info
Publication history
Published online: March 29, 2023
Accepted:
January 26,
2023
Received:
January 25,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
