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Fecal carriage of Extended-Spectrum Beta-lactamase-Producing Enterobacteriaceae in a pediatric intensive care unit in Casablanca, Morocco

  • Author Footnotes
    † Dédith Mbonyingingo and Néhémie Nzoyikorera equally contributed to this work.
    Dédith Mbonyingingo
    Footnotes
    † Dédith Mbonyingingo and Néhémie Nzoyikorera equally contributed to this work.
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Burundi Food and Medicines Regulatory Authority (ABREMA), Bujumbura, Burundi

    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
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  • Author Footnotes
    † Dédith Mbonyingingo and Néhémie Nzoyikorera equally contributed to this work.
    Néhémie Nzoyikorera
    Correspondence
    Corresponding author. Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco,
    Footnotes
    † Dédith Mbonyingingo and Néhémie Nzoyikorera equally contributed to this work.
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Higher Institute of Biosciences and Biotechnology, Mohammed VI University of Health Sciences (UM6SS) Casablanca, Morocco

    Laboratoire National de Référence, Institut National de Santé Publique, Bujumbura, Burundi
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  • Idrissa Diawara
    Affiliations
    Higher Institute of Biosciences and Biotechnology, Mohammed VI University of Health Sciences (UM6SS) Casablanca, Morocco

    Laboratoire National de Référence, Mohammed VI University of Health Sciences (UM6SS) Casablanca, Morocco
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  • Khalid Fdany
    Affiliations
    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
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  • Khalid Katfy
    Affiliations
    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
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  • Fakhreddine Maaloum
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
    Search for articles by this author
  • Joseph Nyandwi
    Affiliations
    Faculté de Médecine, Université du Burundi, Burundi

    Ministère de la Santé Publique et de la Lutte contre le Sida, Institut National de Santé Publique de Bujumbura, Burundi

    Unité de Néphrologie, Centre Hospitalo-Universitaire de Kamenge, Burundi
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  • Abdelaziz Chlilek
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Resuscitation department of the HAROUCHI Abderrahim Children's Hospital of Casablanca, Morocco
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  • Houria Belabbes
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
    Search for articles by this author
  • Naima Elmdaghri
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
    Search for articles by this author
  • Zerouali Khalid
    Affiliations
    Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Morocco

    Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco
    Search for articles by this author
  • Author Footnotes
    † Dédith Mbonyingingo and Néhémie Nzoyikorera equally contributed to this work.
Published:November 22, 2022DOI:https://doi.org/10.1016/j.jhin.2022.09.028
      The discovery of antibiotics has been an important medical advance that improved the prognosis of bacterial infections. Recent trends in hospital antimicrobial resistance show a high prevalence of extended-spectrum-beta-lactamase-producing Enterobacterales (ESBL-PE) (
      • Lucet J.C.
      • Bouadma L.
      Épidémiologie française de l’infection acquise en réanimation.
      ,
      • Nordmann P.
      Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge.
      ). Enterobacterales are distinguished by their capacity to survive and spread in the community and in hospitals, especially in intensive care units (
      • MacVane S.H.
      Antimicrobial Resistance in the Intensive Care Unit: A Focus on Gram-Negative Bacterial Infections.
      ). Colonization is a risk factor for ESBL-PE infections which are associated with increased morbidity, mortality, hospital costs and length of stay (
      • Marchaim D.
      • Gottesman T.
      • Schwartz O.
      • Korem M.
      • Maor Y.
      • Rahav G.
      • et al.
      National Multicenter Study of Predictors and Outcomes of Bacteremia upon Hospital Admission Caused by Enterobacteriaceae Producing Extended-Spectrum β-Lactamases.
      ).
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