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Procalcitonin in cerebrospinal fluid is not helpful for diagnosing external ventricular catheter-associated infection: a prospective study of diagnostic accuracy

Published:November 22, 2022DOI:https://doi.org/10.1016/j.jhin.2022.11.009
      CSF-drainage with an external ventricular drain (EVD) is complicated by a catheter-associated infection in approximately 9% of patients [
      • Jamjoom A.A.B.
      • Joannides A.J.
      • Poon M.T.
      • et al.
      Prospective, multicentre study of external ventricular drainage-realted infections in the UK and Ireland.
      ]. Diagnosing a drain-associated infection can be difficult, especially in case of a CSF-blood mixture [
      • Dorresteijn K.R.I.S.
      • Jellema K.
      • van de Beek D.
      • et al.
      Factors and measures predicting external CSF drain-associated ventriculitis: a review and meta-analysis.
      ]. Procalcitonin (PCT) has been suggested as biomarker to diagnose ventricular catheter-associated infection [
      • Dorresteijn K.R.I.S.
      • Jellema K.
      • van de Beek D.
      • et al.
      Factors and measures predicting external CSF drain-associated ventriculitis: a review and meta-analysis.
      ,
      • Tunkel A.R.
      • Hasbun R.
      • Bhimraj A.
      • et al.
      Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis.
      ]. We aimed to determine the diagnostic accuracy of procalcitonin in CSF and serum over time for diagnosing ventricular catheter-associated infection.

      Keywords

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