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Impact of specimen quality on the performance of culture rectal screening for multi-drug-resistant bacteria

  • R. Le Guen
    Affiliations
    Infection Control Team, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France
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  • G. Royer
    Affiliations
    Bacteriology Unit, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France

    EA 7380 DYNAMYC, Health Faculty, Créteil, France
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  • V. Fihman
    Affiliations
    Bacteriology Unit, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France

    EA 7380 DYNAMYC, Health Faculty, Créteil, France
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  • A. Maurand
    Affiliations
    Infection Control Team, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France
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  • C. Sakr
    Affiliations
    Infection Control Team, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France

    EA 7380 DYNAMYC, Health Faculty, Créteil, France
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  • F. Fourreau
    Affiliations
    Infection Control Team, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France
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  • P.L. Woerther
    Affiliations
    Bacteriology Unit, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France

    EA 7380 DYNAMYC, Health Faculty, Créteil, France
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  • J-W. Decousser
    Correspondence
    Corresponding author. Address: Department of Microbiology, Assistance Publique - Hôpitaux de Paris, University Hospital Henri Mondor, 94000 Créteil, France. Tel.: +33 1 49 81 49 36; fax: +33 1 49 81 28 39.
    Affiliations
    Infection Control Team, Microbiology Department, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France

    EA 7380 DYNAMYC, Health Faculty, Créteil, France
    Search for articles by this author
Published:September 13, 2022DOI:https://doi.org/10.1016/j.jhin.2022.09.002
      Prompt identification of multi-drug-resistant bacteria (MDR) carriers allows implementation of contact precautions to prevent cross-transmission, and can allow earlier implementation of appropriate antibiotic therapy [
      • Tacconelli E.
      • Cataldo M.A.
      • Dancer S.J.
      • De Angelis G.
      • Falcone M.
      • Frank U.
      • et al.
      European Society of Clinical Microbiology guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients.
      ,
      • Cerceo E.
      • Deitelzweig S.B.
      • Sherman B.M.
      • Amin A.N.
      Multidrug-resistant Gram-negative bacterial infections in the hospital setting: overview, implications for clinical practice, and emerging treatment options.
      ,
      Centers for Disease Control and Prevention
      COVID-19: U.S. impact on antimicrobial resistance, special report 2022.
      ]. The reservoir of most MDR bacteria is the digestive tract, and rectal screening is the leading method to detect carriage. To the authors' knowledge, the impact of specimen quality on MDR rectal screening performance has not been studied previously. We implemented a laboratory-based study to address this issue, and proposed practical criteria to interpret a negative screening result.
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