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Short report| Volume 102, ISSUE 4, P461-464, August 2019

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Laboratory exposure to Coccidioides: lessons learnt in a non-endemic country

  • L. Porte
    Correspondence
    Corresponding author. Address: Laboratorio Clínico, Clínica Alemana, Av. Vitacura 5951, Santiago, Chile. Tel.: +56 222101006.
    Affiliations
    Laboratorio Clínico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
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  • F. Valdivieso
    Affiliations
    Programa Medicina del Viajero, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

    Laboratorio de Microbiología, Hospital Luis Calvo Mackenna, Santiago, Chile
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  • D. Wilmes
    Affiliations
    Mycology Section, FG 16, Robert-Koch Institute, Berlin, Germany
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  • P. Gaete
    Affiliations
    Comite IAAS, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago
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  • M.C. Díaz
    Affiliations
    Programa de Microbiologia y Micologia, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
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  • L. Thompson
    Affiliations
    Servicio de Infectología, Departamento de Medicina Interna, Clínica Alemana, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
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  • J.M. Munita
    Affiliations
    Servicio de Infectología, Departamento de Medicina Interna, Clínica Alemana, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

    Genómica & Resistencia Microbiana, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Chile

    Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R)
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  • R. Alliende
    Affiliations
    Laboratorio Clínico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
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  • C. Varela
    Affiliations
    Laboratorio Clínico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
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  • V. Rickerts
    Affiliations
    Mycology Section, FG 16, Robert-Koch Institute, Berlin, Germany
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  • T. Weitzel
    Affiliations
    Laboratorio Clínico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

    Programa Medicina del Viajero, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
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Published:March 15, 2019DOI:https://doi.org/10.1016/j.jhin.2019.03.006

      Summary

      Coccidioides is a primary pathogenic fungus, which infects humans through highly infectious arthroconidia, causing substantial morbidity including life-threatening disseminated infections. Due to the low infectious dose, laboratory personnel might become infected during diagnostic procedures. Accordingly, coccidioidomycosis is reported as the most frequent laboratory-acquired systemic mycosis worldwide. This risk is aggravated in non-endemic countries, where the diagnosis may not be suspected. We report on an inadvertent exposure of 44 persons to Coccidioides posadasii in a clinical microbiology laboratory in Chile, the measures of containment after rapid diagnosis with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and the lessons learnt in a non-endemic setting.

      Keywords

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