Advertisement

Emergence of Candida auris in Russia

Published:March 06, 2019DOI:https://doi.org/10.1016/j.jhin.2019.02.021

      Summary

      This paper reports the emergence of Candida auris infections in an intensive care unit at a hospital in Moscow. Forty-nine cases were diagnosed in 2016–2017, and the risk factors and antifungal susceptibilities are described. The 30-day all-cause mortality for 19 bloodstream infections in patients who did not receive appropriate antifungal therapy was 42.1%. Phylogenetic analysis of the internal transcribed spacer and D1–D2 regions and K143R substitution in the ERG11 gene indicated that the studied C. auris strains were of South Asian origin. This first reported series of C. auris infections in Russia demonstrates the rapid dissemination of this species, and the need for international surveillance and control measures.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hospital Infection
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Satoh K.
        • Makimura K.
        • Hasumi Y.
        • Nishiyama Y.
        • Uchida K.
        • Yamaguchi H.
        Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital.
        Microbiol Immunol. 2009; 53: 41-44
        • Kohlenberg A.
        • Struelens M.J.
        • Monnet D.L.
        • Plachouras D.
        The Candida auris Survey Collaborative Group. Candida auris: epidemiological situation, laboratory capacity and preparedness in European Union and European Economic Area countries, 2013 to 2017.
        Euro Surveill. 2018; 23 (18-00136)
        • Morales-López S.E.
        • Parra-Giraldo C.M.
        • Ceballos-Garzón A.
        • Martínez H.P.
        • Rodríguez G.J.
        • Álvarez-Moreno C.A.
        • et al.
        Invasive infections with multidrug-resistant yeast Candida auris, Colombia.
        Emerg Infect Dis. 2017; 23: 162-164
        • Jeffery-Smith A.
        • Taori S.K.
        • Schelenz S.
        • Jeffery K.
        • Johnson E.M.
        • Borman A.
        • et al.
        Candida auris: a review of the literature.
        Clin Microbiol Rev. 2017; 31 (e00029-17)
        • Ruiz-Gaitán A.
        • Moret A.M.
        • Tasias-Pitarch M.
        • Aleixandre-López A.
        • Martínez-Morel H.
        • Calabuig E.
        • et al.
        An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital.
        Mycoses. 2018; 61: 498-505
        • Kurtzman C.P.
        • Robnett C.J.
        Identification and phylogeny of ascomycetous yeasts from analysis of nuclear large subunit (26S) ribosomal DNA partial sequences.
        Antonie Van Leeuwenhoek. 1998; 73: 331-371
        • Hsiao C.R.
        • Huang L.
        • Bouchara J.P.
        • Barton R.
        • Li H.C.
        • Chang T.C.
        Identification of medically important molds by an oligonucleotide array.
        J Clin Microbiol. 2005; 43: 3760-3768
        • Lockhart S.R.
        • Etienne K.A.
        • Vallabhaneni S.
        • Farooqi J.
        • Chowdhary A.
        • Govender N.P.
        Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses.
        Clin Infect Dis. 2017; 64: 134-140
        • Schelenz S.
        • Hagen F.
        • Rhodes J.L.
        • Abdolrasouli A.
        • Chowdhary A.
        • Hall A.
        • et al.
        First hospital outbreak of the globally emerging Candida auris in a European hospital.
        Antimicrob Resist Infect Control. 2016; 19: 35
        • Cadnum J.L.
        • Shaikh A.A.
        • Piedrahita C.T.
        • Sankar T.
        • Jencson A.L.
        • Larkin E.L.
        • et al.
        Effectiveness of disinfectants against Candida auris and other Candida species.
        Infect Control Hosp Epidemiol. 2017; 38: 1240-1243