Summary
This paper reports the emergence of Candida auris infections in an intensive care unit at a hospital in Moscow. Forty-nine cases were
diagnosed in 2016–2017, and the risk factors and antifungal susceptibilities are described.
The 30-day all-cause mortality for 19 bloodstream infections in patients who did not
receive appropriate antifungal therapy was 42.1%. Phylogenetic analysis of the internal
transcribed spacer and D1–D2 regions and K143R substitution in the ERG11 gene indicated that the studied C. auris strains were of South Asian origin. This first reported series of C. auris infections in Russia demonstrates the rapid dissemination of this species, and the
need for international surveillance and control measures.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Hospital InfectionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital.Microbiol Immunol. 2009; 53: 41-44
- The Candida auris Survey Collaborative Group. Candida auris: epidemiological situation, laboratory capacity and preparedness in European Union and European Economic Area countries, 2013 to 2017.Euro Surveill. 2018; 23 (18-00136)
- Invasive infections with multidrug-resistant yeast Candida auris, Colombia.Emerg Infect Dis. 2017; 23: 162-164
- Candida auris: a review of the literature.Clin Microbiol Rev. 2017; 31 (e00029-17)
- An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital.Mycoses. 2018; 61: 498-505
- Identification and phylogeny of ascomycetous yeasts from analysis of nuclear large subunit (26S) ribosomal DNA partial sequences.Antonie Van Leeuwenhoek. 1998; 73: 331-371
- Identification of medically important molds by an oligonucleotide array.J Clin Microbiol. 2005; 43: 3760-3768
- Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses.Clin Infect Dis. 2017; 64: 134-140
- First hospital outbreak of the globally emerging Candida auris in a European hospital.Antimicrob Resist Infect Control. 2016; 19: 35
- Effectiveness of disinfectants against Candida auris and other Candida species.Infect Control Hosp Epidemiol. 2017; 38: 1240-1243
Article info
Publication history
Published online: March 06, 2019
Accepted:
February 28,
2019
Received:
December 25,
2018
Identification
Copyright
Crown Copyright © 2019 Published by Elsevier Ltd on behalf of The Healthcare Infection Society. All rights reserved.