Advertisement

Pattern of Gram-negative bloodstream infections and their antibiotic susceptibility profiles in a neonatal intensive care unit

Published:November 08, 2017DOI:https://doi.org/10.1016/j.jhin.2017.10.024
      Bloodstream infections (BSIs) are one of the major causes of mortality and morbidity in neonatal intensive care units (NICUs) around the globe [
      • Garg A.
      • Kumar D.
      • Kumar S.
      Microbiological study of neonatal sepsis in a tertiary care hospital of Western Uttar Pradesh, India.
      ]. In developing countries, neonatal sepsis is reported to cause approximately 1.6 million deaths each year [
      • Kishk R.M.
      • Mandour M.F.
      • Farghaly R.M.
      • Ibrahim A.
      • Nemr N.A.
      Pattern of blood stream infections within neonatal intensive care unit, Suez Canal University Hospital, Ismailia, Egypt.
      ]. Neonates, especially low-birthweight and preterm neonates, are at greater risk of becoming colonized by multi-drug-resistant (MDR) and extensively-drug-resistant (XDR) Gram-negative (GN) bacteria [
      • Das P.
      • Singh A.K.
      • Pal T.
      • Dasgupta S.
      • Ramamurthy T.
      • Basu S.
      Colonization of the gut with Gram-negative bacilli, its association with neonatal sepsis and its clinical relevance in a developing country.
      ]. Such bacteria present a major challenge to neonatologists in selecting the correct empiric antibiotic therapy, and also impose a considerable economic burden on healthcare providers and society.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hospital Infection
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Garg A.
        • Kumar D.
        • Kumar S.
        Microbiological study of neonatal sepsis in a tertiary care hospital of Western Uttar Pradesh, India.
        Int J Res Med Sci. 2017; 4: 2701-2704
        • Kishk R.M.
        • Mandour M.F.
        • Farghaly R.M.
        • Ibrahim A.
        • Nemr N.A.
        Pattern of blood stream infections within neonatal intensive care unit, Suez Canal University Hospital, Ismailia, Egypt.
        Int J Microbiol. 2014; 2014276873
        • Das P.
        • Singh A.K.
        • Pal T.
        • Dasgupta S.
        • Ramamurthy T.
        • Basu S.
        Colonization of the gut with Gram-negative bacilli, its association with neonatal sepsis and its clinical relevance in a developing country.
        J Med Microbiol. 2011; 60: 1651-1660
        • Shehab El-Din E.M.
        • El-Sokkary M.M.
        • Bassiouny M.R.
        • Hassan R.
        Epidemiology of neonatal sepsis and implicated pathogens: a study from Egypt.
        BioMed Res Int. 2015; 2015509484
        • Muley V.A.
        • Ghadage D.P.
        • Bhore A.V.
        Bacteriological profile of neonatal septicemia in a tertiary care hospital from Western India.
        J Glob Infect Dis. 2015; 7: 75-77
        • Tzialla C.
        • Borghesi A.
        • Pozzi M.
        • Stronati M.
        Neonatal infections due to multi-resistant strains: epidemiology, current treatment, emerging therapeutic approaches and prevention.
        Clin Chim Acta. 2015; 451: 71-77
        • Wilcox M.H.
        The start of another infection prevention learning curve: reducing healthcare-associated Gram-negative bloodstream infections.
        J Hosp Infect. 2017; 97: 205-206