This article discusses the infection control and public health measures taken whilst managing a case of laboratory-confirmed rabies, and the challenges faced in implementing these measures. Case management requires intensive multi-disciplinary co-ordination. The Milwaukee protocol, which to date has five reported human rabies survivors associated with its use, has been suggested as a potential management pathway for human rabies. Consensus among hospital and public health clinicians would aid future deployment of this approach in selected cases.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Hospital Infection
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The public health management of a suspected case of human rabies.PHE, London2004 ([updated 2009])
- Bat rabies in the United Kingdom: we need to put the risk in context.BMJ. 2005; 330: 491-492
- Case report. Isolation of a European bat Lyssavirus type 2a from a fatal human case of rabies encephalitis.J Med Virol. 2003; 71: 281-289
- Diagnosis, management and post-mortem findings of a human case of rabies imported into the United Kingdom from India: a case report.Virol J. 2014; 11: 63
Children's Hospital of Wisconsin. Rabies registry home page. Milwaukee, MI: Children's Hospital of Wisconsin; 2009. Available at: http://www.chw.org/rabies [last updated November 2016].
- Survival after treatment of rabies with induction of coma.N Engl J Med. 2005; 352: 2508-2514
- Memorandum on rabies prevention and control.DoH, London2000
- Textbook of microbiology (New Delhi). Chapter 66: Rhabdoviruses.JP Medical, 2012
- Safe working and the prevention of infection in the mortuary and post-mortem room.2nd ed. HSE, London2003
- Guidelines on rabies post-exposure treatment.PHE, London2016
- The Green Book (immunisation against infectious disease). Rabies: Chapter 27.Department of Health, London2013 (Available at: https://www.gov.uk/government/publications/rabies-the-green-book-chapter-27 [last accessed May 2017].)
- Biological agents: managing the risks in laboratories and healthcare premises.(Appendix 1.2) ACDP, London2005
- The public health management of a suspected case of human rabies.PHE, London2004
- Rare and emerging viral infections in transplant recipients.Clin Infect Dis. 2013; 57: 1182-1188
- Risk assessment for healthcare workers after a sentinel case of rabies and review of the literature.Clin Infect Dis. 2015; 60: 341-348
- Prevention of inter-human rabies transmission after corneal graft.C R Seances Acad Sci III. 1981; 293: 689-692
- Overview of animal rabies in Kinshasa Province in the Democratic Republic of Congo.PLoS One. 2016; 7: 11
- A case report on indirect transmission of human rabies.J Zhejiang Univ Sci B. 2015; 16: 969-970
- Viral RNA in the bloodstream suggests viremia occurs in clinically ill rabies-infected mice.Virus Res. 2006; 116: 114-118
- Rabies bulletin Europe.WHO, Geneva2012 (Available at: http://www.who-rabies-bulletin.org [last accessed May 2017].)
- Rabies: guidance on prophylaxis and management in humans in Scotland.Health Protection Scotland, Glasgow2013
Published online: May 02, 2017
Accepted: April 21, 2017
Received: January 25, 2017
Crown Copyright © 2017 Published by Elsevier Ltd on behalf of The Healthcare Infection Society. All rights reserved.