Short Report| Volume 96, ISSUE 2, P189-191, June 2017

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Lack of antimicrobial efficacy of mecetronium etilsulfate in propanol-based hand rubs for surgical hand disinfection

  • G. Kampf
    Address: Institute for Hygiene and Environmental Medicine, University Medicine Greifswald, Walter-Rathenau-Straße 49 A, 17475 Greifswald, Germany.
    Knieler und Team GmbH, Infection Control Science, Hamburg, Germany

    Institute for Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany
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Published:March 03, 2017DOI:


      The aim of this study was to determine if mecetronium etilsulfate (MES) contributes to overall efficacy in surgical hand disinfection. Three blinded hand rubs (45% iso-propanol, 30% n-propanol) were applied for 1.5 min and compared with the EN 12791 reference procedure (crossover design). One commercial hand rub contained 0.2% MES, and the two other hand rubs were identical apart from 0.2% MES. None of the formulations had a log10 reduction after 3 h that was significantly better compared with the reference procedure [mean 1.72 (standard deviation 1.15)]. The antimicrobial contribution of MES in hand rubs is questionable.


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        • EN 12791:2015
        Chemical disinfectants and antiseptics. Surgical hand disinfection. Test method and requirement (phase 2, step 2).
        CEN - Comité Européen de Normalisation, Brussels2015
        • Kampf G.
        • Kramer A.
        • Suchomel M.
        Lack of sustained efficacy for alcohol-based surgical hand rubs containing “residual active ingredients” according to EN 12791.
        J Hosp Infect. 2017; 95: 163-168
        • World Health Organization
        Global guidelines for the prevention of surgical site infections.
        WHO, Geneva2016
        • Proske O.
        • Sauermann G.
        • Pietsch H.
        • Rohde B.
        Die Hautverträglichkeit von Mecetroniumetilsulfat in einem Desinfektionsmittel – eine klinische Studie.
        Hygiene und Medizin. 1995; 20: 535-542
        • Slotosch C.M.
        • Kampf G.
        • Löffler H.
        Effects of disinfectants and detergents on skin irritation.
        Contact Dermatitis. 2007; 57: 235-241
        • Kampf G.
        • Wigger-Alberti W.
        • Wilhelm K.P.
        Do atopics tolerate alcohol-based hand rubs? A prospective, controlled, randomized double-blind clinical trial.
        Acta Dermato-Venereol. 2006; 86: 140-143
        • Tluczkiewicz I.
        • Bitsch A.
        • Hahn S.
        • Hahn T.
        Emission of biocides from hospitals: comparing current survey results with European Union default values.
        Integr Environ Assess Manag. 2010; 6: 273-280
        • Holmes A.H.
        • Moore L.S.
        • Sundsfjord A.
        • Steinbakk M.
        • Regmi S.
        • Karkey A.
        • et al.
        Understanding the mechanisms and drivers of antimicrobial resistance.
        Lancet. 2016; 387: 176-187
        • Aktion Saubere Hände
        Positionspapier: Verträglichkeit von Händedesinfektionsmitteln.
        Wissenschaftlicher Beirat der Aktion Saubere Hände, Berlin2010 (Available at: http://wwwaktion-sauberehaendede/fileadmin/ash/downloads/pdf/ASH_Positionspapier_Hautschutz_Hautpflege_Farb-Paruemfrei_112010pdf [last accessed June 2016])
        • Kampf G.
        Acquired resistance to chlorhexidine – is it time to establish an “antiseptic stewardship” initiative?.
        J Hosp Infect. 2016; 94: 213-227