Post-prescription review of hospital antibiotic therapy may contribute to more appropriate use. We estimated the impact of a standardised review of intravenous antibiotic therapy three days after prescription in two internal medicine wards of a university hospital. In one ward, we assessed the charts of patients under intravenous antibiotic therapy using a standardised review process and provided feedback to the prescriber. There was no intervention in the other ward. After six months we crossed the allocation between the two wards. In all, 204 courses of antibiotic therapy were included in the intervention periods and 226 in the control periods. Post-prescription review led to proposals for modification in 46% of antibiotic courses. Time to treatment modification was 22% shorter in the intervention periods compared with the control periods (3.9±5.2 days vs 5.0±6.0 days, P=0.007). Patients included in the intervention group had lower antibiotic consumption than patients in the control group, but the intervention had no significant impact on the overall antibiotic consumption of the two wards.
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Published online: May 17, 2010
Accepted: July 15, 2009
Received: February 16, 2009
☆This study was presented in part at the 44th Annual Meeting of the Infectious Diseases Society of America (IDSA), 12–15 October 2006 in Toronto, Ontario, Canada.
© 2009 The Hospital Infection Society. Published by Elsevier Inc. All rights reserved.