Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus

Summary 

Background

Noroviruses are a leading cause of gastrointestinal disease and are of particular concern in healthcare settings such as hospitals. As the virus is reported to be environmentally stable, effective decontamination following an outbreak is required to prevent recurrent outbreaks.

Aim

To investigate the use of hydrogen peroxide vapour to decontaminate a number of surfaces that had been artificially contaminated with feline calicivirus (FCV), a surrogate for norovirus. The surfaces tested were representative of those found in hospital wards.

Methods

FCV was used to contaminate materials representative of a hospital setting (stainless steel, glass, vinyl flooring, ceramic tile and PVC plastic cornering). The carriers were exposed to 30% (w/w) hydrogen peroxide vapour at 5-min intervals over 20min, after which postexposure viral titres were measured.

Findings

Hydrogen peroxide vapour reduced the viral titre by 4 log₁₀ on all surfaces tested within 20min of exposure. The reduction in viral titre took longest to achieve on stainless steel (20min), and the quickest effect was seen on vinyl flooring (10min). For glass, plastic and ceramic tile surfaces, the desired reduction in viral titre was seen within 15min of exposure. Hydrogen peroxide vapour allows for large-scale decontamination of areas following outbreaks of infectious organisms.

Conclusion

Hydrogen peroxide vapour is effective against FCV and is active on a range of surfaces. Therefore, it may represent a suitable decontamination system for use following a hospital outbreak of norovirus.

Keywords: Norovirus, FCV, Hydrogen peroxide vapour, Decontamination