Journal of Hospital Infection
Volume 76, Issue 2 , Pages 108-113 , October 2010

Epidemiology meets econometrics: using time-series analysis to observe the impact of bed occupancy rates on the spread of multidrug-resistant bacteria

  • K. Kaier

      Affiliations

    • Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
    • Research Center for Generational Contracts, Freiburg University, Freiburg, Germany
    • Corresponding Author InformationCorresponding author. Address: Department of Environmental Health Sciences, University Medical Center Freiburg, Breisacher Straße 115b, D-79106 Freiburg, Germany. Tel.: +49 761 270 8272; fax: +49 761 270 8253.
    • ,
  • E. Meyer

      Affiliations

    • Institute of Hygiene and Environmental Medicine, Charité, Medical University, Berlin, Germany
    • ,
  • M. Dettenkofer

      Affiliations

    • Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
    • ,
  • U. Frank

      Affiliations

    • Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany

Received 18 May 2009 ,Accepted 2 April 2010.

References 

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  3. Kaier K, Wilson C, Chalkley M, et al. Health and economic impacts of antibiotic resistance in European hospitals – outlook on the BURDEN Project. Infection. 2008;36:492–494
  4. Meyer E, Gastmeier P, Schwab F. The burden of multiresistant bacteria in German intensive care units. J Antimicrob Chemother. 2008;62:1474–1476
  5. Lopez-Lozano JM, Monnet DL, Yague A, et al. Modelling and forecasting antimicrobial resistance and its dynamic relationship to antimicrobial use: a time series analysis. Int J Antimicrob Agents. 2000;14:21–31
  6. Monnet DL, Lopez-Lozano JM, Campillos P, Burgos A, Yague A, Gonzalo N. Making sense of antimicrobial use and resistance surveillance data: application of ARIMA and transfer function models. Clin Microbiol Infect. 2001;7:29–36
  7. Kritsotakis EI, Christidou A, Roumbelaki M, Tselentis Y, Gikas A. The dynamic relationship between antibiotic use and the incidence of vancomycin-resistant Enterococcus: time-series modelling of 7-year surveillance data in a tertiary-care hospital. Clin Microbiol Infect. 2008;14:747–754
  8. Monnet DL, MacKenzie FM, Lopez-Lozano JM, et al. Antimicrobial drug use and meticillin-resistant Staphylococcus aureus, Aberdeen, 1996–2000. Emerg Infect Dis. 2004;10:1432–1441
  9. Borg MA. Bed occupancy and overcrowding as determinant factors in the incidence of MRSA infections within general ward settings. J Hosp Infect. 2003;54:316–318
  10. Borg MA, Suda D, Scicluna E. Time-series analysis of the impact of bed occupancy rates on the incidence of meticillin-resistant Staphylococcus aureus infection in overcrowded general wards. Infect Control Hosp Epidemiol. 2008;29:496–502
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  14. Bignardi GE, Askew C. Workload may be related to the spread of MRSA and other infections. J Hosp Infect. 2000;45:78–80
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  16. Grundmann H, Hori S, Winter B, Tami A, Austin DJ. Risk factors for the transmission of meticillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data. J Infect Dis. 2002;185:481–488
  17. Nijssen S, Bonten MJM, Franklin C, Verhoef J, Hoepelman AIM, Weinstein RA. Relative risk of physicians and nurses to transmit pathogens in a medical intensive care unit. Arch Intern Med. 2003;163:2785–2786
  18. Pittet D, Mourouga P, Perneger TV the Members of the Infection Control Program. Compliance with handwashing in a teaching hospital. Ann Intern Med. 1999;130:126–130
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  20. Kaier K, Hagist C, Frank U, Conrad A, Meyer E. Two time-series analyses of the impact of antibiotic consumption and alcohol-based hand disinfection on the incidences of nosocomial meticillin-resistant Staphylococcus aureus infection and Clostridium difficile infection. Infect Control Hosp Epidemiol. 2009;30:346–353
  21. Kaier K, Frank U, Hagist C, Conrad A, Meyer E. The impact of antimicrobial drug consumption and alcohol-based hand rub use on the emergence and spread of extended-spectrum β-lactamase-producing strains: a time-series analysis. J Antimicrob Chemother. 2009;63:609–614
  22. Scott RD, Solomon SL, McGowan JE. Applying economic principles to health care. Emerg Infect Dis. 2001;7:282–285

PII: S0195-6701(10)00214-8

doi: 10.1016/j.jhin.2010.04.010

Journal of Hospital Infection
Volume 76, Issue 2 , Pages 108-113 , October 2010

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